Description

3A,4,5,6,7,7A-Hexahydro-1-(Trimethylsilyl)-4,7-Methano-1H-Benzotriazole is a specialized organosilicon heterocyclic compound that serves as a versatile building block and protective agent in advanced organic synthesis. Its unique fused bicyclic structure, incorporating a silylated benzotriazole moiety, makes it a valuable reagent for introducing functional groups with high selectivity and stability. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures. Its application extends to materials science, where it is used in the synthesis of novel polymers and functionalized surfaces.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structural complexity can contribute to new modes of action.
• Organometallic Catalyst Ligand: Acts as a precursor or ligand in catalysis, potentially modifying the activity and selectivity of transition metal catalysts for asymmetric synthesis.
• Polymer Modification: Employed to introduce triazole and silane functionalities into polymer backbones, enhancing properties like adhesion, thermal stability, or chemical resistance.
• Surface Functionalization Agent: Used to create self-assembled monolayers (SAMs) or to covalently attach specific functional groups to silicon, glass, or metal oxide surfaces for sensor or electronic applications.
• Protecting Group in Peptide Synthesis: The trimethylsilyl group can serve as a temporary protecting group for sensitive functionalities during multi-step synthetic sequences.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, enabling new cycloaddition or cross-coupling reactions.

Basic Information

Product Name	3A,4,5,6,7,7A-Hexahydro-1-(Trimethylsilyl)-4,7-Methano-1H-Benzotriazole
CAS No.	17843-09-3
Molecular Formula	C11H19N3Si
Molecular Weight	221.38 g/mol
Synonyms	1-(Trimethylsilyl)-4,7-methano-1H-benzotriazole, 4,7-Methano-1H-benzotriazole, 1-(trimethylsilyl)-, hexahydro-; 1H-Benzotriazole, 3a,4,5,6,7,7a-hexahydro-1-(trimethylsilyl)-4,7-methano-; 1-Trimethylsilyl-4,7-methanohexahydrobenzotriazole; TMS-Methanobenzotriazole; N-Trimethylsilyl-4,7-methano-1H-benzotriazole
EINECS	Contact for details

Quality Control

Our production of 3A,4,5,6,7,7A-Hexahydro-1-(Trimethylsilyl)-4,7-Methano-1H-Benzotriazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with relevant regulatory frameworks for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining the product under an inert atmosphere (e.g., nitrogen or argon) to prevent potential oxidation or moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.