Description

sec-Butyl Chloroformate is a versatile and highly reactive alkyl chloroformate ester used as a key reagent in organic synthesis. Its primary value lies in its role as a protecting group agent and an intermediate for introducing the sec-butoxycarbonyl moiety, enabling the synthesis of complex molecules. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical sectors, where it facilitates peptide coupling and the production of carbamates and carbonates. The CAS number for this compound is provided in the table below.

Application

sec-Butyl Chloroformate (CAS 17462-58-7) is employed in various sophisticated chemical processes. Its applications include:

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in peptide and prodrug development.
• Agrochemical Production: Serves as a building block for herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Used as a modifying agent or initiator in the production of specialized polymers and resins.
• Protecting Group in Organic Synthesis: Effectively protects amine and alcohol functional groups during multi-step synthetic sequences.
• Carbamate Synthesis: A key reagent for preparing sec-butyl carbamate derivatives.
• Chemical Research & Development: Utilized in laboratories for method development and scaling novel synthetic routes.

Basic Information

Product Name	sec-Butyl Chloroformate
CAS No.	17462-58-7
Molecular Formula	C5H9ClO2
Molecular Weight	136.58 g/mol
Synonyms	sec-Butyl chlorocarbonate; Butan-2-yl chloroformate; 2-Butyl chloroformate; Chloroformic acid sec-butyl ester; sec-BuOCOCl; 1-Methylpropyl chloroformate; 2-Chlorocarbonyloxybutane
EINECS	241-486-8

Quality Control

Our sec-Butyl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable. Comprehensive testing, including assay and impurity profiling by GC and/or HPLC, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.03 - 1.07 g/mL
Refractive Index (n20D)	1.405 - 1.415

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.