Description

1-Azetidinesulfonyl Chloride, 2,2-Dimethyl-4-Oxo- is a high-value, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. This compound is critical for introducing the 2,2-dimethyl-4-oxo-azetidine scaffold, a structure of significant interest in medicinal chemistry and materials science. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel drug candidates, particularly those targeting protease inhibition or requiring constrained ring systems.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, where the sulfonyl chloride moiety enables the creation of potent herbicides or fungicides.
• Peptidomimetics & Bioactive Molecule Synthesis: Facilitates the incorporation of the azetidine ring into peptide backbones and other bioactive compounds to modulate stability, potency, and pharmacokinetic properties.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating specialty polymers with unique thermal or mechanical characteristics.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific, high-purity intermediate.

Basic Information

Product Name	1-Azetidinesulfonyl Chloride, 2,2-Dimethyl-4-Oxo-
CAS No.	17174-96-8
Molecular Formula	C5H8ClNO3S
Molecular Weight	197.64 g/mol
Synonyms	2,2-Dimethyl-4-oxoazetidine-1-sulfonyl chloride; 4-Oxo-2,2-dimethylazetidine-1-sulfonyl chloride; 2,2-Dimethyl-4-oxo-1-azetidinesulfonyl chloride; 1-(Chlorosulfonyl)-2,2-dimethyl-4-azetidinone; 2,2-Dimethyl-4-azetidinone-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Azetidinesulfonyl Chloride, 2,2-Dimethyl-4-Oxo- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.