Description

(4-Bromobenzyl)Trimethylsilane is a versatile organosilicon compound featuring a bromobenzyl group, making it a valuable protected intermediate in synthetic organic chemistry. Its primary value lies in its dual functionality, where the trimethylsilyl (TMS) group acts as a protective moiety for the benzyl position, while the bromine atom serves as a reactive handle for further cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing substituted benzyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromobenzyl structure is a core component.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis, such as Suzuki-Miyaura and Heck cross-coupling reactions.
• Advanced Material Monomer: Employed in the research and development of organic electronic materials, including OLEDs and semiconductors, where its structure can be incorporated into conjugated systems.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex organic molecules, leveraging the TMS group for selective deprotection and functionalization strategies.
• Chemical Research Reagent: Acts as a standard or starting material in methodological studies for new synthetic transformations involving organosilicon chemistry.

Basic Information

Product Name	(4-Bromobenzyl)Trimethylsilane
CAS No.	17095-20-4
Molecular Formula	C10H15BrSi
Molecular Weight	243.22 g/mol
Synonyms	1-(Bromomethyl)-4-(trimethylsilyl)benzene; p-Bromobenzyltrimethylsilane; 4-Bromobenzyltrimethylsilane; Trimethyl(4-bromobenzyl)silane; (p-Bromobenzyl)trimethylsilane; (4-Bromophenylmethyl)trimethylsilane; Bromobenzyltrimethylsilane; TMS-Protected 4-Bromobenzyl Bromide Derivative
EINECS	Contact for details

Quality Control

Our (4-Bromobenzyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry inert atmosphere to maximize shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Assay (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.