Description

H-Ser(Tbu)-Ome Hcl is a protected serine derivative, specifically the tert-butyl ether of serine methyl ester hydrochloride salt. This compound is a crucial building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), where it serves to protect the reactive hydroxyl group during coupling reactions. It is essential for research and production in pharmaceutical development, particularly for creating peptide-based therapeutics and novel drug candidates.

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Serves as a critical building block in the manufacture of peptide-based Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Used in academic and industrial R&D for studying protein structure-function relationships and designing novel biomolecules.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening.
• Glycopeptide Synthesis: Acts as a precursor in the synthesis of glycopeptides and other post-translationally modified peptides.
• Protecting Group Strategy: Utilized in multi-step organic syntheses where selective protection and deprotection of functional groups are required.

Basic Information

Product Name	H-Ser(Tbu)-Ome Hcl
CAS No.	17083-26-0
Molecular Formula	C9H20ClNO4
Molecular Weight	241.71 g/mol
Synonyms	L-Serine, O-tert-butyl-, methyl ester, hydrochloride; Methyl O-tert-butyl-L-serinate hydrochloride; H-Ser(OtBu)-OMe·HCl; Fmoc-Ser(tBu)-OH methyl ester hydrochloride; Serine, O-(1,1-dimethylethyl)-, methyl ester, hydrochloride, (S)-; (2S)-2-Amino-3-[(2-methylpropan-2-yl)oxy]propanoic acid methyl ester hydrochloride; O-tert-Butyl-L-serine methyl ester hydrochloride; Boc-Ser(tBu)-OMe hydrochloride (common error, but often searched)
EINECS	Contact for details

Quality Control

Our H-Ser(Tbu)-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for peptide synthesis intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.