Description

L-n-Cbz-3-n-Boc-Amino-Alanine is a protected amino acid derivative, specifically engineered for advanced peptide synthesis. This compound is crucial for researchers and manufacturers requiring precise control over side-chain functionality during complex multi-step organic syntheses. It serves as a key chiral building block for the development of novel pharmaceuticals, bioactive peptides, and sophisticated chemical probes.

Application

• Pharmaceutical Intermediates: A critical chiral synthon in the synthesis of complex peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of alanine with orthogonal side-chain protection (Cbz and Boc).
• Bioconjugation & Probe Development: Serves as a building block for creating labeled peptides, affinity tags, and molecular probes for biochemical research.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening applications.
• Academic & Industrial R&D: A valuable reagent for research in medicinal chemistry, chemical biology, and synthetic methodology development.

Basic Information

Product Name	L-n-Cbz-3-n-Boc-Amino-Alanine
CAS No.	16947-84-5
Molecular Formula	C16H22N2O6
Molecular Weight	338.36 g/mol
Synonyms	Nα-Cbz-Nβ-Boc-L-2,3-diaminopropionic acid; Nα-Carbobenzoxy-Nβ-tert-butoxycarbonyl-L-2,3-diaminopropanoic acid; (S)-2-(((Benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)propanoic acid; L-2,3-Diaminopropionic acid, Nα-Cbz, Nβ-Boc; Cbz-Dpr(Boc)-OH; Fmoc-Dap(Boc)-OH precursor; Boc-Dap(Cbz)-OH
EINECS	Contact for details

Quality Control

Our L-n-Cbz-3-n-Boc-Amino-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.