Description

(1R,2R,5R)-2-Isopropyl-5-Methylcyclohexanamine is a high-purity, stereochemically defined chiral amine of significant commercial interest. This compound serves as a critical chiral building block and intermediate in the synthesis of complex molecules, offering precise control over stereochemistry. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where enantiomeric purity directly impacts product efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and pesticides, where specific stereochemistry enhances biological activity and reduces environmental impact.
• Catalyst and Ligand Precursor: Serves as a starting material for synthesizing chiral catalysts and ligands used in asymmetric synthesis, enabling high-yield, stereoselective reactions.
• Flavor and Fragrance Industry: Employed as an intermediate for creating specific stereoisomers of aroma chemicals and flavor compounds, where the isomeric form defines the sensory profile.
• Advanced Material Research: Investigated as a monomer or modifying agent for chiral polymers and liquid crystals with potential applications in optics and electronics.
• Academic and R&D Laboratories: A valuable reference standard and reagent for methodological development in organic chemistry and stereochemistry studies.

Basic Information

Product Name	(1R,2R,5R)-2-Isopropyl-5-Methylcyclohexanamine
CAS No.	16934-77-3
Molecular Formula	C10H21N
Molecular Weight	155.28 g/mol
Synonyms	(1R,2R,5R)-(-)-Menthylamine; (1R,2R,5R)-2-Isopropyl-5-methylcyclohexanamine; (-)-Menthylamine; L-Menthylamine; (1R,2R,5R)-(-)-2-Isopropyl-5-methylcyclohexanamine; (1R,2R,5R)-1-Amino-2-isopropyl-5-methylcyclohexane; (1R,2R,5R)-2-(1-Methylethyl)-5-methylcyclohexanamine
EINECS	Contact for details

Quality Control

Our (1R,2R,5R)-2-Isopropyl-5-Methylcyclohexanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and GC analysis, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	-25° to -30° (c=1 in Ethanol)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.