Description

2-Tetrahydrofuroic Acid is a versatile heterocyclic carboxylic acid derivative, serving as a key chiral building block and intermediate in advanced organic synthesis. Its value lies in its unique fused ring structure, which provides a rigid framework for constructing complex molecules with specific stereochemistry. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of various active pharmaceutical ingredients (APIs), including potential antiviral and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require specific stereochemical configurations for efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control reaction stereoselectivity.
• Polymer Modification: Employed as a monomer or modifying agent to introduce functional groups into polymers, enhancing properties like biodegradability or adhesion.
• Flavor and Fragrance Industry: Acts as an intermediate in the synthesis of certain lactones and other compounds used to create complex aroma profiles.
• Academic and R&D: A valuable reagent in medicinal chemistry and organic synthesis research for exploring new chemical entities and reaction pathways.

Basic Information

Product Name	2-Tetrahydrofuroic Acid
CAS No.	16874-33-2
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	Dihydro-2-furancarboxylic Acid; Tetrahydro-2-furoic Acid; 2-Furancarboxylic Acid, Tetrahydro-; α-Tetrahydrofuroic Acid; 2-Tetrahydrofurancarboxylic Acid; THFA; 2-Carboxytetrahydrofuran; (Tetrahydrofuran-2-yl)carboxylic Acid
EINECS	240-904-7

Quality Control

Our 2-Tetrahydrofuroic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with key parameters including assay, chiral purity (enantiomeric excess), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage under an inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (e.e.)	≥ 99.0% (Specific enantiomer available)
Melting Point	88 - 92 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.