Description

Trimethylsilyl Butyrate is a versatile organosilicon compound used as a silylating agent and synthetic intermediate. Its primary value lies in its ability to protect reactive functional groups, such as hydroxyls and carboxylic acids, during complex chemical synthesis. This makes it a critical reagent for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to improve reaction yields and product stability.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for protecting sensitive functional groups during multi-step reactions.
• Agrochemical Synthesis: Serves as a key building block in the production of advanced pesticides and herbicides.
• Polymer Modification: Employed to introduce silyl groups into polymer chains, altering surface properties and stability.
• Derivatization Agent for GC/MS: Used to silylate polar compounds (e.g., acids, alcohols) for improved volatility and detection in gas chromatography-mass spectrometry analysis.
• Flavor and Fragrance Ingredient Synthesis: Acts as an intermediate in the creation of complex ester-based aroma chemicals.
• Surface Treatment Reagent: Applied in the modification of silica and other inorganic surfaces to impart hydrophobic characteristics.

Basic Information

Product Name	Trimethylsilyl Butyrate
CAS No.	16844-99-8
Molecular Formula	C7H16O2Si
Molecular Weight	160.29 g/mol
Synonyms	Butanoic Acid Trimethylsilyl Ester; Butyric Acid Trimethylsilyl Ester; Trimethylsilyl Butanoate; TMS-Butyrate; NSC 5188; Silyl Butyrate, Trimethyl-; (Trimethylsilyl) Butyrate
EINECS	240-877-7

Quality Control

Our Trimethylsilyl Butyrate is produced under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, NMR, and Karl Fischer titration to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at temperatures between 15-25°C. Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider using an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.405 - 1.415
Density (20°C)	0.85 - 0.90 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.