Description

2(3H)-Benzofuranone, Hexahydro-4,4,7A-Trimethyl- is a high-purity, saturated lactone derivative with a complex bicyclic structure, serving as a versatile and valuable synthetic intermediate. Its rigid molecular framework and functional group make it a critical building block for creating complex molecules with specific stereochemistry and properties. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its structure contributes to biological activity and environmental stability.
• Fragrance & Flavor Chemistry: Acts as a starting material for synthesizing musk-like odorants and complex flavor compounds due to its lactone functionality.
• Fine Chemical Building Block: Employed in organic synthesis for constructing complex polycyclic frameworks found in natural products and specialty chemicals.
• Material Science Research: Investigated as a monomer or modifier for producing specialized polymers with unique thermal or mechanical properties.
• Catalyst & Ligand Development: Serves as a scaffold for developing novel chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	2(3H)-Benzofuranone, Hexahydro-4,4,7A-Trimethyl-
CAS No.	16778-27-1
Molecular Formula	C11H18O2
Molecular Weight	182.26 g/mol
Synonyms	Hexahydro-4,4,7a-trimethyl-2(3H)-benzofuranone; 4,4,7a-Trimethylhexahydro-2-benzofuranone; 4,4,7a-Trimethylhexahydro-2(3H)-benzofuranone; 2-Oxabicyclo[4.3.0]nonan-8-one, 4,4,7a-trimethyl-; 4,4,7a-Trimethylhexahydrobenzofuran-2(3H)-one; Dihydroambrettolide (trade/aroma context); 7a-Methyl-4,4-dimethylhexahydro-2-benzofuranone
EINECS	240-842-9

Quality Control

Our 2(3H)-Benzofuranone, Hexahydro-4,4,7A-Trimethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, GC for residual solvents, and chiral analysis to ensure it meets precise customer specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We can supply material compliant with ICH Q7 guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.