Description

Retinoxytrimethylsilane is a specialized organosilicon derivative of retinoic acid, designed to enhance stability and delivery in advanced formulations. This compound is valued for its ability to combine the biological activity of retinoids with the favorable handling and stability properties of silyl ethers. It is primarily utilized by R&D and production teams in the pharmaceutical, advanced dermatology, and high-performance cosmetic industries seeking innovative active ingredients.

Application

• Pharmaceutical Intermediates: Serves as a key synthetic building block or prodrug form for novel retinoid-based therapeutics.
• Advanced Cosmetic Actives: Used in the development of premium anti-aging, skin-renewal, and photodamage repair serums and creams for enhanced skin penetration and stability.
• Dermatological Preparations: Incorporated into prescription and clinical-grade formulations targeting acne, psoriasis, and other skin conditions.
• Bioconjugation & Prodrug Development: Acts as a versatile linker or modifying agent in drug delivery system research to improve pharmacokinetic profiles.
• Chemical Synthesis: Employed in organic synthesis as a protected or modified form of retinoic acid for creating novel chemical entities.
• Research & Development: A critical reagent for academic and industrial research exploring new retinoid signaling pathways and material applications.

Basic Information

Product Name	Retinoxytrimethylsilane
CAS No.	16729-19-4
Molecular Formula	C23H38O2Si
Molecular Weight	374.63 g/mol
Synonyms	All-trans-Retinoxytrimethylsilane; Retinoic Acid Trimethylsilyl Ester; Trimethylsilyl Retinoate; Vitamin A Acid Trimethylsilyl Ester; TMS-Retinoate; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid Trimethylsilyl Ester; Retinoyloxytri(methyl)silane
EINECS	Contact for details

Quality Control

Our Retinoxytrimethylsilane is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for research and production use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. The material is easily oxidized and light-sensitive; allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.