Description

N(Alpha)-Ethoxycarbonyl-L-Asparagine is a protected derivative of the amino acid L-asparagine, featuring an ethoxycarbonyl group on the α-amino nitrogen. This modification is crucial for its primary role as a key chiral building block and intermediate in the synthesis of complex peptides and pharmaceutical compounds. It is essential for research and production chemists in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity, enantiomerically pure intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the L-asparagine residue while protecting the α-amino group.
• Biochemical Research: Serves as a reagent in proteomics research and for studying enzyme-substrate interactions.
• Fine Chemical Production: Employed in the manufacture of specialized agrochemicals, flavors, and fragrances requiring specific chirality.
• Protecting Group Chemistry: The ethoxycarbonyl (EOC or Z) group provides temporary protection for the amino function during multi-step synthetic sequences.

Basic Information

Product Name	N(Alpha)-Ethoxycarbonyl-L-Asparagine
CAS No.	16639-91-1
Molecular Formula	C8H14N2O5
Molecular Weight	218.21 g/mol
Synonyms	Nα-Carbobenzoxy-L-asparagine; Nα-Z-L-Asparagine; Z-L-Asparagine; Nα-(Benzyloxycarbonyl)-L-asparagine; (S)-2-((Benzyloxycarbonyl)amino)-3-carbamoylpropanoic acid; N-CBZ-L-Asparagine; L-Asparagine, N-[(phenylmethoxy)carbonyl]-; NSC 3349
EINECS	240-699-5

Quality Control

Our N(Alpha)-Ethoxycarbonyl-L-Asparagine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets high-purity standards suitable for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -12.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.