Description

Trimethylsilyl Radical is a highly reactive organosilicon intermediate, pivotal for introducing the trimethylsilyl (TMS) protecting group in complex organic syntheses. Its primary value lies in enabling selective reactions and protecting sensitive functional groups, which is critical for achieving high yields and purity in advanced chemical manufacturing. This compound is essential for R&D chemists and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is paramount.

Application

• As a key reagent for the protection of alcohols, carboxylic acids, and amines in multi-step pharmaceutical synthesis.
• As a silylating agent in the production of specialty silicones and silane coupling agents for surface modification.
• In semiconductor manufacturing for chemical vapor deposition (CVD) processes and surface passivation.
• As an intermediate in the synthesis of organometallic catalysts and ligands used in polymerization and fine chemical production.
• For derivatization in gas chromatography (GC) to improve the volatility and detection of polar analytes.
• In advanced material research, including the development of silicon-based polymers and nanomaterials.

Basic Information

Product Name	Trimethylsilyl Radical
CAS No.	16571-41-8
Molecular Formula	C₃H₉Si•
Molecular Weight	73.18 g/mol
Synonyms	Trimethylsilyl; TMS Radical; (CH₃)₃Si•; Trimethylsilyl Free Radical; Silyl, trimethyl-; Trimethylsilyl Group; Trimethylsilyl Radical (TMS•); (Trimethylsilyl) Radical
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Radical is manufactured under stringent conditions to ensure batch-to-batch consistency and high reactivity. Quality is verified through advanced analytical techniques including NMR and GC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this material must be stored under an inert atmosphere (e.g., nitrogen or argon) at recommended temperatures. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution / gas
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 95% (typical)
Solvent (if applicable)	Specified inert solvent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.