Description

5-Chloro-3,4-Dihydro-8-Hydroxy-3-Methyl-1H-2-Benzopyran-1-One-7-Carboxylic Acid is a high-purity, synthetically derived organic compound serving as a critical advanced intermediate in pharmaceutical research and development. Its complex benzopyranone-carboxylic acid structure makes it a valuable building block for synthesizing novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex heterocyclic scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or plant growth regulators that leverage its chlorinated benzopyranone structure.
• Fine Chemical Synthesis: Serves as a versatile precursor for creating specialty chemicals, dyes, and functional materials.
• Biochemical Tool Compound: Potential use in biochemical assays and as a research probe to study enzyme inhibition or receptor binding due to its specific functional groups.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies and novel synthetic route exploration.

Basic Information

Product Name	5-Chloro-3,4-Dihydro-8-Hydroxy-3-Methyl-1H-2-Benzopyran-1-One-7-Carboxylic Acid
CAS No.	16281-39-3
Molecular Formula	C11H9ClO5
Molecular Weight	256.64 g/mol
Synonyms	5-Chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid; 5-Chloro-8-hydroxy-3-methylisochroman-1-one-7-carboxylic acid; 7-Carboxy-5-chloro-8-hydroxy-3-methylisochroman-1-one; 5-Chloro-7-carboxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin; 16281-39-3; 5-Chloro-8-hydroxy-3-methyl-3,4-dihydroisocoumarin-7-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-3,4-Dihydro-8-Hydroxy-3-Methyl-1H-2-Benzopyran-1-One-7-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, and NMR for comprehensive characterization and impurity profiling. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with each shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.