Description

(2S,4R)-4-Aminopyrrolidine-2-Carboxylic Acid Dihydrochloride is a high-purity, non-proteinogenic amino acid derivative with a constrained pyrrolidine ring structure. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical synthesis, particularly for the development of novel therapeutics. It is essential for research and production in medicinal chemistry, enabling the creation of complex molecules with specific stereochemical configurations. Key industries that rely on this material include pharmaceutical R&D, biotechnology, and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics & Drug Discovery: Used to construct conformationally restricted peptide analogs and novel scaffolds in medicinal chemistry programs.
• Bioconjugation & Linker Chemistry: Serves as a functionalized component for creating antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Catalyst & Ligand Synthesis: Employed in the preparation of chiral catalysts and ligands for asymmetric synthesis.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies and biochemical assays.
• Fine Chemical Production: An important intermediate for manufacturing specialty chemicals with high stereochemical purity.

Basic Information

Product Name	(2S,4R)-4-Aminopyrrolidine-2-Carboxylic Acid Dihydrochloride
CAS No.	16257-89-9
Molecular Formula	C5H10N2O2 • 2HCl
Molecular Weight	215.07 g/mol
Synonyms	(2S,4R)-4-Aminopyrrolidine-2-carboxylic acid hydrochloride; (2S,4R)-4-Amino-L-proline dihydrochloride; cis-4-Amino-L-proline dihydrochloride; (2S,4R)-4-Aminoproline dihydrochloride; 4-Amino-L-proline dihydrochloride (cis); L-cis-4-Hydroxyproline analog dihydrochloride; 4-Amino-2-carboxypyrrolidine dihydrochloride; 16257-89-9
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Aminopyrrolidine-2-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.