Description

(2S,4S)-4-Bromopyrrolidine-2-Carboxylic Acid CAS NO 16257-69-5 is a high-purity, chiral non-natural amino acid derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling precise control over the three-dimensional architecture of target compounds. This product is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other bioactive molecules.
• Peptidomimetics & Drug Discovery: Used to incorporate constrained pyrrolidine motifs into peptide backbones, enhancing metabolic stability and biological activity.
• Agrochemical Research: Serves as a precursor for developing chiral herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized to create labeled or modified amino acids for studying biological pathways and protein function.
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(2S,4S)-4-Bromopyrrolidine-2-Carboxylic Acid
CAS No.	16257-69-5
Molecular Formula	C5H8BrNO2
Molecular Weight	194.03 g/mol
Synonyms	(2S,4S)-4-Bromo-2-pyrrolidinecarboxylic Acid; (4S)-4-Bromoproline; (2S,4S)-4-Bromoproline; 4-Bromo-L-proline; L-4-Bromoproline; 4-Bromo-(S)-proline; 4-Bromopyrrolidine-2-carboxylic acid, (2S,4S)-; 16257-69-5
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Bromopyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full characterization data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.