Description

Ethyl 3-(Trimethylsilyl)Propiolate is a versatile organosilicon building block featuring both a silyl-protected acetylene and an ester functional group. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in advanced research and industrial chemistry. It is particularly sought after by pharmaceutical, agrochemical, and materials science laboratories for constructing carbon frameworks and introducing functional handles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing alkyne-containing scaffolds and heterocycles.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides, leveraging its reactivity for carbon-carbon bond formation.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, silicon-based coatings, and advanced materials.
• Organic Synthesis Building Block: Employed in Sonogashira coupling, click chemistry, and other palladium-catalyzed reactions to introduce acetylene units into target molecules.
• Liquid Crystal & OLED Research: Acts as a precursor for synthesizing conjugated organic molecules used in electronic and photonic materials.
• Chemical Derivatization: Utilized for protecting group strategies and as a reagent for introducing the trimethylsilylpropiolate moiety into complex structures.

Basic Information

Product Name	Ethyl 3-(Trimethylsilyl)Propiolate
CAS No.	16205-84-8
Molecular Formula	C8H14O2Si
Molecular Weight	170.28 g/mol
Synonyms	Ethyl 3-(Trimethylsilyl)prop-2-ynoate; Ethyl Trimethylsilylpropiolate; 3-(Trimethylsilyl)propiolic Acid Ethyl Ester; TMS-Propiolic Acid Ethyl Ester; Ethyl (Trimethylsilyl)ethynoate; Propiolic acid, 3-(trimethylsilyl)-, ethyl ester; Ethyl β-(Trimethylsilyl)propiolate
EINECS	Contact for details

Quality Control

Our Ethyl 3-(Trimethylsilyl)Propiolate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.