Description

3,4-Bis(Trimethylsilyl)-1H-Pyrazole is a versatile organosilicon-protected pyrazole derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected intermediate, enabling the controlled functionalization of the pyrazole ring system under demanding reaction conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those containing functionalized pyrazole cores for therapeutic applications.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the pyrazole moiety is a critical pharmacophore.
• Organometallic Chemistry: Acts as a ligand precursor or a protected reagent in the synthesis of metal-organic complexes and catalysts.
• Material Science Research: Employed in the creation of novel organic semiconductors, ligands for metal-organic frameworks (MOFs), and other functional materials.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions like Suzuki or Stille couplings after appropriate functional group manipulation.
• Chemical Library Development: A valuable scaffold for combinatorial chemistry and high-throughput screening in drug discovery programs.

Basic Information

Product Name	3,4-Bis(Trimethylsilyl)-1H-Pyrazole
CAS No.	16037-45-9
Molecular Formula	C9H22N2Si2
Molecular Weight	214.46 g/mol
Synonyms	1H-Pyrazole, 3,4-bis(trimethylsilyl)-; 3,4-Bis(trimethylsilyl)pyrazole; 3,4-Bis(trimethylsilyl)-1H-pyrazole; Pyrazole, 3,4-bis(trimethylsilyl)-; 1H-Pyrazole, 3,4-bis[(trimethylsilyl)]-; 3,4-Bis(trimethylsilyl)pyrazole; 3,4-Bis(trimethylsilyl)-1H-pyrazole (stabilized)
EINECS	Contact for details

Quality Control

Our 3,4-Bis(Trimethylsilyl)-1H-Pyrazole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for your synthetic workflows. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.