Description

Hydroxymethyl-7-Aminocephalosporanic Acid (CAS NO 15690-38-7) is a crucial advanced pharmaceutical intermediate in the synthesis of semi-synthetic cephalosporin antibiotics. Its primary value lies in providing the core chemical scaffold for developing potent, broad-spectrum antibacterial agents. This compound is essential for manufacturers in the pharmaceutical industry, particularly those focused on active pharmaceutical ingredient (API) production for injectable and oral antibiotic formulations.

Application

• Key Intermediate for Cephalosporin API Synthesis: Serves as the foundational building block for manufacturing a wide range of semi-synthetic cephalosporin antibiotics.
• Pharmaceutical R&D: Used in research laboratories for the development of new-generation cephalosporin drugs with improved efficacy and resistance profiles.
• Production of Cefotaxime and Related Derivatives: A critical precursor in the chemical synthesis pathway for cefotaxime sodium and other third-generation cephalosporins.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized antibiotic intermediates under cGMP conditions.

Basic Information

Product Name	Hydroxymethyl-7-Aminocephalosporanic Acid
CAS No.	15690-38-7
Molecular Formula	C10H12N2O5S
Molecular Weight	272.28 g/mol
Synonyms	7-ACA Hydroxymethyl Derivative; (6R,7R)-3-(Hydroxymethyl)-8-oxo-7-amino-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; HM-7-ACA; 3-Hydroxymethyl-7-aminocephalosporanic Acid; 7-Amino-3-hydroxymethyl-3-cephem-4-carboxylic Acid; Cephalosporin C Nucleus Derivative
EINECS	Contact for details

Quality Control

Our Hydroxymethyl-7-Aminocephalosporanic Acid is produced and tested to meet stringent quality standards suitable for pharmaceutical intermediate applications. We employ rigorous analytical controls, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical parameters. Production can be aligned with cGMP guidelines for API synthesis upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.