Description

Lithium Aluminium Di-n-Butylamide is a highly reactive organometallic compound belonging to the class of lithium amide bases. This specialized reagent is valued for its strong, non-nucleophilic basicity, making it a powerful tool for deprotonation reactions in sensitive synthetic sequences. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex organic molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Synthesis: As a strong, sterically hindered base for regioselective deprotonation in the synthesis of complex drug molecules and advanced intermediates.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances where controlled deprotonation under mild conditions is required.
• Polymer Chemistry: Used as an initiator or catalyst in the anionic polymerization of specific monomers to create polymers with controlled architectures.
• Academic & Industrial R&D: A key reagent in methodological development and exploratory synthesis for new chemical entities.
• Lithium Chemistry: Serves as a precursor or reagent in the preparation of other organolithium compounds or complex metal hydrides.
• Asymmetric Synthesis: Potential application in chiral auxiliary-based reactions for the generation of enantiomerically enriched compounds.

Basic Information

Product Name	Lithium Aluminium Di-n-Butylamide
CAS No.	15405-86-4
Molecular Formula	C8H18AlLiN
Molecular Weight	147.15 g/mol
Synonyms	Lithium Di-n-butylamidoaluminium Hydride; Lithium Aluminum Di-n-butylamide; Di-n-butylamidolithium Aluminium Hydride; LDBBA; Lithium Di-n-butylamidoalane; (Di-n-butylamido)lithium Aluminium Hydride; Lithium Di-sec-butylamidoaluminium Hydride (related); Lithium Dialkylamidoaluminium Hydride (class)
EINECS	Contact for details

Quality Control

Our Lithium Aluminium Di-n-Butylamide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Production adheres to cGMP principles where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, impurity profile, and solution concentration (if supplied as a solution). We are committed to meeting the exacting standards required for research and process-scale applications.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Handle and open containers only in a certified inert atmosphere glovebox or under a continuous flow of dry inert gas.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution or solid
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0% (or as specified for solution in toluene/hexanes)
Solvent (if supplied as solution)	Toluene, Hexanes, or THF
Concentration (if supplied as solution)	Typically 1.0 M, customizable

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.