Description

o-(Trimethylsilyl)Phenol is a versatile organosilicon intermediate featuring a reactive phenolic hydroxyl group protected by a trimethylsilyl moiety. This compound matters for its dual functionality, serving as a key building block in the synthesis of advanced materials and specialty chemicals where precise silicon-oxygen-carbon linkages are required. Industries such as pharmaceuticals, agrochemicals, and polymer science need it for creating siloxane-based polymers, liquid crystals, and as a protective group in complex organic synthesis.

Application

• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly where silicon incorporation modifies bioavailability or stability.
• Agrochemical Synthesis: Serves as a precursor for silicon-containing pesticides, herbicides, and plant growth regulators.
• Polymer & Material Science: A key monomer for producing specialized siloxane polymers, resins, and high-performance silicones with enhanced thermal and chemical resistance.
• Liquid Crystal Production: Employed in the manufacture of silicon-based liquid crystal compounds for display technologies.
• Surface Modification Agent: Used to functionalize silica surfaces and other inorganic materials, altering their hydrophobicity and reactivity.
• Protective Group Chemistry: The trimethylsilyl group acts as a temporary protecting group for phenolic hydroxyls in multi-step organic syntheses.
• Adhesive & Sealant Formulations: Imparts specific curing and bonding properties in advanced silicone-based adhesives and sealants.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new organosilicon chemistry and material properties.

Basic Information

Product Name	o-(Trimethylsilyl)Phenol
CAS No.	15288-53-6
Molecular Formula	C9H14OSi
Molecular Weight	166.29 g/mol
Synonyms	2-(Trimethylsilyl)phenol; Phenol, 2-(trimethylsilyl)-; o-Hydroxyphenyltrimethylsilane; 2-Hydroxyphenyltrimethylsilane; Trimethyl(2-hydroxyphenyl)silane; (2-Hydroxyphenyl)trimethylsilane; TMS-Phenol (o-isomer); 2-TMS-Phenol
EINECS	Contact for details

Quality Control

Our o-(Trimethylsilyl)Phenol is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.