Description

1-Methoxy-4-Trifluoromethanesulfonyl-Benzene is a high-purity, versatile aryl trifluoromethanesulfonate (triflate) building block essential for advanced organic synthesis. Its core value lies in its exceptional reactivity as a leaving group, enabling efficient cross-coupling reactions and the introduction of the methoxyaryl moiety into complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing active pharmaceutical ingredients (APIs), functional ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions for synthesizing novel drug candidates and APIs.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Catalyst Ligand Preparation: Used to synthesize sophisticated phosphine or N-heterocyclic carbene (NHC) ligands for homogeneous catalysis.
• Chemical Research & Development: Versatile reagent in academic and industrial labs for methodological studies and constructing complex, functionalized arenes.
• Fine Chemical Production: Intermediate in the multi-step synthesis of dyes, flavors, and fragrances.

Basic Information

Product Name	1-Methoxy-4-Trifluoromethanesulfonyl-Benzene
CAS No.	15183-74-1
Molecular Formula	C8H7F3O4S
Molecular Weight	256.20 g/mol
Synonyms	4-Methoxyphenyl trifluoromethanesulfonate; p-Methoxyphenyl triflate; 1-Methoxy-4-(trifluoromethanesulfonyl)benzene; 4-Methoxybenzenesulfonyl fluoride, 1,1,1-trifluoro-; 4-Methoxyphenyl trifluoromethyl sulfonate; Trifluoromethanesulfonic acid 4-methoxyphenyl ester; Anisole, 4-(trifluoromethanesulfonyl)-
EINECS	Contact for details

Quality Control

Our 1-Methoxy-4-Trifluoromethanesulfonyl-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and lot-to-lot consistency. Certificates of Analysis (COA) with full traceability are provided for each shipment, supporting compliance with cGMP and ISO 9001 standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its reactivity as a strong acid/organic solvent derivative, ensure containers are kept tightly sealed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.