Description

2,2,5,5-Tetramethyltetrahydrofuran is a specialized, highly volatile cyclic ether solvent with a unique sterically hindered structure. This compound matters for its excellent solvating power and stability, making it a valuable intermediate and reaction medium in advanced organic synthesis. It is needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring high-purity, non-reactive solvents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Specialty Solvent: Used as a high-performance reaction medium for organometallic chemistry, Grignard reactions, and polymerization processes where moisture sensitivity is a concern.
• Agrochemical Synthesis: Employed in the production of advanced pesticides and herbicides due to its chemical stability and solvation properties.
• Ligand and Catalyst Preparation: Acts as a precursor or solvent in the synthesis of specialized ligands and catalysts for asymmetric synthesis.
• Electronic Chemicals: Utilized in the purification and processing of materials for the electronics industry.
• Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic pathways and material science.

Basic Information

Product Name	2,2,5,5-Tetramethyltetrahydrofuran
CAS No.	15045-43-9
Molecular Formula	C8H16O
Molecular Weight	128.21 g/mol
Synonyms	2,2,5,5-Tetramethyloxolane; Tetramethyltetrahydrofuran; TMTHF; 2,2,5,5-Tetramethyl-tetrahydrofuran; 2,2,5,5-Tetramethylfuranidine; NSC 66490; 1-Oxaspiro[2.3]hexane, 4,4-dimethyl- (related structure)
EINECS	239-112-6

Quality Control

Our 2,2,5,5-Tetramethyltetrahydrofuran is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and ignition points. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20/D)	1.408 - 1.412
Density (g/mL at 20°C)	0.825 - 0.835
Boiling Point	~ 115-117 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.