Description

1-Benzyl-2,3-o-Isopropylidene Glycerol is a protected glycerol derivative, a versatile chiral building block and intermediate in organic synthesis. Its value lies in the orthogonal protection of the glycerol backbone, allowing for selective functionalization of the primary hydroxyl group. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-blockers, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral pesticides, herbicides, and plant growth regulators.
• Lipid & Glycerophospholipid Chemistry: Serves as a foundational unit for constructing complex lipids, phospholipids, and glyceryl ethers for research and commercial applications.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers with tailored properties.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective reactions to introduce specific three-dimensional configurations.
• Protecting Group Strategy: The isopropylidene group provides a stable, acid-labile protection for diols, crucial in multi-step synthetic pathways.

Basic Information

Product Name	1-Benzyl-2,3-o-Isopropylidene Glycerol
CAS No.	15028-56-5
Molecular Formula	C13H18O3
Molecular Weight	222.28 g/mol
Synonyms	1-O-Benzyl-2,3-O-isopropylidene-sn-glycerol; (R)-1-O-Benzyl-2,3-O-isopropylideneglycerol; (R)-1-Benzyloxy-2,3-isopropylidenedioxypropane; 1-Benzyl-2,3-O-cyclohexylidene glycerol; Benzyl isopropylidene glycerol; sn-1-O-Benzyl-2,3-O-isopropylideneglycerol; Glycerol 1-benzyl ether, 2,3-acetonide
EINECS	Contact for details

Quality Control

Our 1-Benzyl-2,3-o-Isopropylidene Glycerol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay, enantiomeric excess, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and acids. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (R-isomer typical)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.