Description

(1S,2S)-Cyclopropane-1,2-Dicarboxylic Acid is a high-purity, chiral dicarboxylic acid derivative of cyclopropane, serving as a critical building block in asymmetric synthesis. This compound matters for its ability to impart unique stereochemical and conformational rigidity to target molecules, enabling the development of advanced pharmaceuticals and agrochemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and catalyst development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where its rigid cyclopropane structure enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating novel polymers with specific mechanical or thermal properties.
• Academic and R&D: A valuable reagent for methodological development in organic synthesis and stereochemistry research.
• Fine Chemical Production: Employed in the manufacture of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	(1S,2S)-Cyclopropane-1,2-Dicarboxylic Acid
CAS No.	14590-54-6
Molecular Formula	C5H6O4
Molecular Weight	130.10 g/mol
Synonyms	(1S,2S)-1,2-Cyclopropanedicarboxylic Acid; (1S,2S)-Cyclopropane-1,2-dicarboxylic Acid; (1S,2S)-trans-Cyclopropane-1,2-dicarboxylic Acid; (1S,2S)-trans-1,2-Cyclopropanedicarboxylic Acid; (1S-cis)-1,2-Cyclopropanedicarboxylic Acid; L-trans-Cyclopropane-1,2-dicarboxylic Acid; (-)-trans-Cyclopropane-1,2-dicarboxylic Acid
EINECS	Contact for details

Quality Control

Our (1S,2S)-Cyclopropane-1,2-Dicarboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	168 - 172 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.