Description

4-Fluorophenyltrimethylstannane is a versatile organotin reagent featuring a fluorinated aromatic ring, widely utilized in advanced organic synthesis. This compound is valued for its role as a key coupling partner in Stille cross-coupling reactions, enabling the efficient construction of complex biaryl and heteroaryl structures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the 4-fluorophenyl moiety enhances biological activity and stability.
• Materials Science: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic applications.
• Stille Cross-Coupling Reactions: Serves as a reliable organotin nucleophile for palladium-catalyzed coupling with aryl/vinyl halides or triflates.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry in constructing diverse fluorinated aromatic scaffolds.
• Ligand Precursor: Can be used to prepare specialized ligands for catalysis.

Basic Information

Product Name	4-Fluorophenyltrimethylstannane
CAS No.	14101-14-5
Molecular Formula	C9H13FSn
Molecular Weight	258.90 g/mol
Synonyms	Trimethyl(4-fluorophenyl)stannane; (4-Fluorophenyl)trimethyltin; 4-Fluorophenyltrimethyltin; 4-Fluoro-1-trimethylstannylbenzene; 1-Fluoro-4-(trimethylstannyl)benzene; NSC 168103; Stannane, trimethyl(4-fluorophenyl)-; (p-Fluorophenyl)trimethylstannane
EINECS	Contact for details

Quality Control

Our 4-Fluorophenyltrimethylstannane is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (1H, 13C, 19F), GC/HPLC assay, and tin content analysis, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere (argon/nitrogen) to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Tin (Sn) Content	45.0 - 46.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.