Description

4-(Bromomethyl)Phenylacetic Acid is a versatile bifunctional organic building block featuring both a bromomethyl group and a carboxylic acid moiety. This compound is highly valued in synthetic organic chemistry for its role as a key intermediate in the construction of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists for applications in cross-coupling reactions, nucleophilic substitutions, and as a precursor for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphine ligands or metal-organic frameworks (MOFs) used in catalysis.
• Peptidomimetics and Bioconjugation: The carboxylic acid group enables amide bond formation for creating peptide analogs or linker molecules in bioconjugation chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers or organic electronic materials due to its aromatic and reactive halogen structure.
• Cross-Coupling Reactions: The bromomethyl group is an effective handle for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.

Basic Information

Product Name	4-(Bromomethyl)Phenylacetic Acid
CAS No.	13737-36-5
Molecular Formula	C9H9BrO2
Molecular Weight	229.07 g/mol
Synonyms	4-(Bromomethyl)benzeneacetic Acid; (4-Bromomethylphenyl)acetic Acid; 2-[4-(Bromomethyl)phenyl]acetic Acid; p-(Bromomethyl)phenylacetic Acid; α-(4-Bromomethylphenyl)acetic Acid; NSC 403697; BRN 2048381
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)Phenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.