Description

(S)-3-Tosyltetrahydrofuran CAS NO 13694-84-3 is a high-value chiral building block and pharmaceutical intermediate characterized by its tetrahydrofuran core with a tosyl-protected alcohol group. This compound is essential for the stereoselective synthesis of complex molecules, enabling the production of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly for central nervous system (CNS) and antiviral applications.
• Asymmetric Synthesis: Used as a precursor for constructing complex molecular architectures via stereocontrolled chemical transformations.
• Agrochemical Research: Serves as a building block for developing novel, chiral pesticides and herbicides with improved efficacy.
• Catalyst Ligand Development: Employed in the research and preparation of chiral ligands for asymmetric catalysis.
• Academic & R&D Laboratories: Utilized in methodological studies and the discovery of new synthetic routes in organic chemistry.
• Fine Chemical Production: Integral to the manufacture of specialty and performance chemicals requiring high optical purity.

Basic Information

Product Name	(S)-3-Tosyltetrahydrofuran
CAS No.	13694-84-3
Molecular Formula	C11H14O3S
Molecular Weight	226.29 g/mol
Synonyms	(S)-3-(p-Toluenesulfonyloxy)tetrahydrofuran; (S)-Tetrahydro-3-furyl 4-methylbenzenesulfonate; (S)-3-Hydroxytetrahydrofuran 3-tosylate; (S)-3-OTs-THF; (3S)-3-[(4-Methylphenyl)sulfonyl]oxytetrahydrofuran; (S)-3-Tosyloxytetrahydrofuran; (S)-3-Tosyloxy-tetrahydrofuran; (S)-Tetrahydrofuran-3-yl tosylate
EINECS	Contact for details

Quality Control

Our (S)-3-Tosyltetrahydrofuran is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess (ee), and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.