Description

cis-2-Phenylcyclopropylamine is a chiral cyclopropylamine derivative featuring a phenyl substituent, serving as a versatile and valuable building block in advanced organic synthesis. Its constrained cyclopropane ring and primary amine functionality make it a critical intermediate for constructing complex molecules with specific stereochemistry. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) active drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics and Bioisosteres: The rigid cyclopropane ring is employed to replace peptide bonds or other moieties to improve metabolic stability and bioavailability in drug candidates.
• Material Science Research: Intermediate for synthesizing specialty polymers and advanced organic materials with unique optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	cis-2-Phenylcyclopropylamine
CAS No.	13531-35-6
Molecular Formula	C9H11N
Molecular Weight	133.19 g/mol
Synonyms	(1R,2S)-2-Phenylcyclopropanamine; (1S,2R)-2-Phenylcyclopropanamine; trans-2-Phenylcyclopropylamine (Note: often refers to the opposite enantiomer or mixture); 2-Phenylcyclopropanamine; 2-Phenylcyclopropylamine; (±)-cis-2-Phenylcyclopropylamine; DL-cis-2-Phenylcyclopropylamine; 1-Amino-2-phenylcyclopropane
EINECS	Contact for details

Quality Control

Our cis-2-Phenylcyclopropylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC/GC), enantiomeric excess, and impurities is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This amine compound is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee (for enantiopure grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.