Description

2-Trimethylsilyl-1,2,3-Triazole is a versatile organosilicon-protected triazole derivative, a key building block in modern synthetic organic chemistry. Its primary value lies in its role as a stable, protected synthon for the introduction of the 1,2,3-triazole moiety, a crucial pharmacophore and functional group in material science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for applications in click chemistry, heterocyclic synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediates: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) containing the 1,2,3-triazole core, which is prevalent in drugs with antiviral, antibacterial, and anticancer properties.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and insecticides where the triazole ring enhances biological activity and stability.
• Click Chemistry Reagent: Serves as a protected reagent in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other click reactions for bioconjugation and polymer functionalization.
• Material Science & Polymers: Incorporated into advanced polymers, coatings, and functional materials to impart specific chemical or physical properties through the triazole linkage.
• Ligand & Catalyst Development: Utilized as a precursor for creating N-heterocyclic carbene (NHC) ligands and other catalytic systems in organometallic chemistry.
• Research & Development: A valuable tool for academic and industrial R&D chemists exploring new synthetic methodologies and heterocyclic compound libraries.

Basic Information

Product Name	2-Trimethylsilyl-1,2,3-Triazole
CAS No.	13518-80-4
Molecular Formula	C5H11N3Si
Molecular Weight	141.25 g/mol
Synonyms	1H-1,2,3-Triazole, 2-(trimethylsilyl)-; 2-(Trimethylsilyl)-1H-1,2,3-triazole; 2-TMS-1,2,3-triazole; Trimethylsilyltriazole; (1,2,3-Triazol-2-yl)trimethylsilane; 2-Trimethylsilyl-1H-[1,2,3]triazole; TMS-Triazole
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilyl-1,2,3-Triazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry inert atmosphere to maximize shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.