Description

Proline, 4-Ethoxy-, L-cis- (8Ci) is a specialized, non-proteinogenic amino acid derivative characterized by its unique ethoxy substitution at the 4-position of the proline ring. This structural modification makes it a valuable chiral building block and intermediate for advanced organic synthesis, particularly in the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and industrial R&D departments focused on medicinal chemistry, peptide mimetics, and asymmetric catalysis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptidomimetics & Drug Design: Used to introduce conformational constraints and novel functionalities into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Asymmetric Catalysis: Acts as a precursor for designing novel chiral ligands and organocatalysts used in stereoselective synthesis.
• Biochemical Research: Employed as a probe or standard in studies investigating amino acid metabolism, enzyme specificity, and protein structure-function relationships.
• Agrochemical Development: Potential use as an intermediate in the synthesis of advanced, chiral crop protection agents.

Basic Information

Product Name	Proline, 4-Ethoxy-, L-cis- (8Ci)
CAS No.	13500-57-7
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	L-cis-4-Ethoxyproline; (2S,4S)-4-Ethoxyproline; cis-4-Ethoxy-L-proline; 4-Ethoxy-L-proline; 4-Ethoxypyrrolidine-2-carboxylic acid, (2S,4S)-; 4-Ethoxy-DL-proline (mixture); 4-Ethoxyproline
EINECS	Contact for details

Quality Control

Our Proline, 4-Ethoxy-, L-cis- (8Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-cis isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.