Description

Acetyltrimethylsilane is a highly versatile organosilicon compound, valued for its role as a key building block and protecting group in advanced organic synthesis. Its high volatility and reactivity make it an essential reagent for introducing the trimethylsilylacetylene moiety, a fundamental unit in the construction of complex molecular architectures. This product is critical for R&D and production within the pharmaceutical, agrochemical, and advanced materials sectors, where precise chemical modifications are required.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing alkynyl-linked structures.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that require specific acetylene-based functional groups.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty silicon-based polymers and resins.
• Organic Synthesis Reagent: Functions as a protected acetylene equivalent in Sonogashira coupling and other palladium-catalyzed cross-coupling reactions.
• Chemical Research: Employed in academic and industrial laboratories for method development and the synthesis of novel organic compounds.
• Surface Modification: Utilized to introduce hydrophobic trimethylsilyl groups onto various material surfaces.

Basic Information

Product Name	Acetyltrimethylsilane
CAS No.	13411-48-8
Molecular Formula	C5H12Si
Molecular Weight	100.23 g/mol
Synonyms	Trimethylsilylacetylene; Ethynyltrimethylsilane; TMS-acetylene; (Trimethylsilyl)ethyne; Trimethylsilylethyne; TMSA; Acetylene, trimethylsilyl-; 1-Trimethylsilylacetylene
EINECS	236-471-5

Quality Control

Our Acetyltrimethylsilane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analysis, including assay by GC and identity confirmation by FT-IR or NMR spectroscopy. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat, sparks, and open flames. Due to its high volatility, containers must be kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	0.71 - 0.73 g/mL
Refractive Index (n20D)	1.390 - 1.395

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.