Description

Bicyclo[3.1.0]Hexane-3-Carboxylic Acid is a high-purity, strained bicyclic carboxylic acid building block of significant interest in advanced organic synthesis. Its unique fused three- and five-membered ring structure provides a rigid, three-dimensional scaffold that is highly valuable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, fragment-based drug discovery, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for synthesizing novel drug candidates with complex three-dimensional architectures, potentially improving target selectivity and metabolic stability.
• Medicinal Chemistry & SAR Studies: Used in structure-activity relationship (SAR) exploration to introduce conformational constraint into lead compounds, fine-tuning potency and pharmacokinetic profiles.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides, fungicides, or insecticides with novel modes of action, leveraging its unique bicyclic framework.
• Advanced Material Precursor: Can be utilized in the synthesis of specialty monomers or ligands for catalysts used in polymer science and material research.
• Academic & Industrial R&D: Essential for methodological development in organic synthesis, particularly in studies involving strained ring systems and cyclopropane chemistry.
• Fragment-Based Drug Discovery (FBDD): Its rigid, "lead-like" structure makes it a valuable fragment for screening against biological targets to identify novel binding motifs.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-3-Carboxylic Acid
CAS No.	13388-51-7
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	3-Bicyclo[3.1.0]hexanecarboxylic acid; Bicyclo[3.1.0]hexane-3-carboxylic acid; 3-Carboxybicyclo[3.1.0]hexane; (1R,5S)-Bicyclo[3.1.0]hexane-3-carboxylic acid (for enantiopure forms); (1S,5R)-Bicyclo[3.1.0]hexane-3-carboxylic acid; BCHCA; 3-Norcarenecarboxylic acid
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks under cGMP or ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.