Description

(Trans)-4-Propyl-1-Methyl-L-Proline is a high-purity, non-proteinogenic proline derivative characterized by its specific stereochemistry and alkyl substitution. This compound is a critical chiral building block and intermediate in advanced organic synthesis, offering precise structural control for complex molecule construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized catalysts.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, particularly in peptide-based drug discovery.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and modulate the biological activity, stability, and bioavailability of peptide analogs.
• Asymmetric Catalysis: Acts as a precursor or ligand component in the design of chiral catalysts for enantioselective synthesis.
• Chemical Biology & Proteomics: Employed as a tool compound or labeled analog for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Utilized in the synthesis of novel, biologically active compounds for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(Trans)-4-Propyl-1-Methyl-L-Proline
CAS No.	13380-36-4
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	(2S,4S)-4-Propyl-1-methylpyrrolidine-2-carboxylic acid; L-Proline, 4-propyl-1-methyl-, trans-; trans-4-Propyl-1-methyl-L-proline; 1-Methyl-4-propyl-L-proline; (4S)-1-Methyl-4-propyl-L-proline; (2S,4S)-1-Methyl-4-propylproline
EINECS	Contact for details

Quality Control

Our (Trans)-4-Propyl-1-Methyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.