Description

5-(Trimethylsilyl)-4-Pentyn-1-ol is a versatile organosilicon building block featuring both a terminal alkyne and a protected alcohol functional group. This bifunctional nature makes it a critical intermediate in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as click chemistry, cross-coupling reactions, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs) and complex bioactive molecules via Sonogashira coupling and other metal-catalyzed reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the silyl-protected alkyne moiety allows for selective functionalization.
• Polymer & Materials Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, dendrimers, and silicon-containing hybrid materials.
• Click Chemistry Reagent: The terminal alkyne group is ideal for Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) to create triazole linkages.
• Ligand & Catalyst Development: Employed in the synthesis of novel organometallic complexes and chiral ligands for asymmetric catalysis.
• Protecting Group Strategy: The trimethylsilyl group acts as a protective moiety for the alkyne, allowing sequential, orthogonal deprotection and reaction strategies in multi-step syntheses.

Basic Information

Product Name	5-(Trimethylsilyl)-4-Pentyn-1-ol
CAS No.	13224-84-5
Molecular Formula	C8H16OSi
Molecular Weight	156.30 g/mol
Synonyms	4-Pentyn-1-ol, 5-(trimethylsilyl)-; 5-(Trimethylsilyl)pent-4-yn-1-ol; (4-Hydroxybut-1-yn-1-yl)trimethylsilane; 5-Trimethylsilyl-4-pentyn-1-ol; TMS-Protected 4-Pentyn-1-ol; Trimethyl(4-hydroxybut-1-yn-1-yl)silane
EINECS	Contact for details

Quality Control

Our 5-(Trimethylsilyl)-4-Pentyn-1-ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including GC, NMR, and HPLC to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles for manufacturing, ensuring reliability for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.