Description

Triisobutylchlorosilane is a highly reactive organosilicon compound, specifically a chlorosilane, widely used as a versatile silylating agent and key intermediate in organic synthesis. Its primary value lies in its ability to introduce the bulky triisobutylsilyl (TIBS) protecting group, which offers superior steric hindrance for sensitive synthetic pathways. This makes it an essential reagent for pharmaceutical R&D, agrochemical production, and advanced material science, where precise molecular modification and protection are critical.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis and protection of complex drug molecules, particularly in nucleoside and steroid chemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides as a protecting group for alcohols and other functional groups.
• Polymer & Material Science: Serves as a surface modifying agent and crosslinker in the development of silicone-based polymers and specialty coatings.
• Organic Synthesis: A fundamental silylating agent for protecting hydroxyl groups (-OH) during multi-step synthetic sequences.
• Chemical Research & Development: Critical tool in laboratory-scale R&D for exploring new synthetic methodologies and creating novel organosilicon compounds.
• Production of Silane Coupling Agents: Acts as a precursor for manufacturing other functional silanes used to improve adhesion between organic and inorganic materials.

Basic Information

Product Name	Triisobutylchlorosilane
CAS No.	13154-25-1
Molecular Formula	C12H27ClSi
Molecular Weight	234.88 g/mol
Synonyms	Chlorotriisobutylsilane; TIBS-Cl; Triisobutylsilyl chloride; Silane, chlorotriisobutyl-; NSC 163083; (i-Bu)3SiCl; Triisobutylchlorosilane; Chlorotriisobutylsilane
EINECS	236-107-3

Quality Control

Our Triisobutylchlorosilane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay by GC or titration and impurity profiling, to meet exacting customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat and ignition sources. Due to its hygroscopic and highly volatile nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Density (at 20°C)	0.88 - 0.90 g/mL
Refractive Index (n20/D)	1.450 - 1.455
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.