Description

tert-Butoxytrimethylsilane is a versatile organosilicon reagent primarily used as a protecting agent and silylating agent in organic synthesis. Its value lies in its ability to introduce the bulky tert-butoxytrimethylsilyl group, which offers unique steric and electronic properties for modifying molecular reactivity and stability. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthetic pathways.

Application

• Protecting Group in Organic Synthesis: Used to protect hydroxyl groups (as tert-butoxytrimethylsilyl ethers), offering an alternative to traditional silyl ethers with different cleavage properties.
• Silylating Agent: Employed to derivatize sensitive functional groups for analysis or to alter solubility and volatility characteristics of target molecules.
• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds.
• Precursor in Materials Science: Acts as a starting material or modifying agent in the production of specialty silicones, surface coatings, and silane coupling agents.
• Cross-Coupling Reactions: Can be utilized in palladium-catalyzed reactions and other metal-mediated transformations where silicon-based reagents are required.
• Laboratory Reagent: A valuable tool for method development and research in academic and industrial R&D laboratories focusing on synthetic chemistry.

Basic Information

Product Name	tert-Butoxytrimethylsilane
CAS No.	13058-24-7
Molecular Formula	C7H18OSi
Molecular Weight	146.30 g/mol
Synonyms	tert-Butyloxytrimethylsilane; Trimethyl-tert-butoxysilane; (tert-Butoxy)trimethylsilane; Silane, tert-butoxytrimethyl-; TBSO-t-Bu; t-Butoxytrimethylsilane; tert-Butyl Trimethylsilyl Ether; TBOTMS
EINECS	235-940-7

Quality Control

Our tert-Butoxytrimethylsilane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production, ensuring reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Containers must be kept tightly sealed when not in use to prevent evaporation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	0.76 - 0.78 g/mL
Refractive Index (n20D)	1.390 - 1.395

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.