Description

Homocysteine Thiolactone is a cyclic thioester derivative of the amino acid homocysteine, serving as a key intermediate in metabolic and biochemical research. Its significance lies in its role as a model compound for studying homocysteine metabolism, protein homocysteinylation, and associated cellular stress pathways. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors, where it is used in the development of assays, reference standards, and investigative studies related to cardiovascular and neurological health.

Application

• Biochemical Research: Critical intermediate for studying homocysteine metabolism and its implications in cardiovascular disease, neurodegenerative disorders, and endothelial dysfunction.
• Pharmaceutical Development: Used as a reference standard and building block in the synthesis of potential therapeutic agents targeting hyperhomocysteinemia.
• Diagnostic Reagents: Serves as a key component in the formulation of enzymatic and immunoassay kits for the quantitative determination of homocysteine levels in biological samples.
• Metabolic Pathway Analysis: Employed in in vitro and cell-based studies to investigate the mechanisms of protein damage via N-homocysteinylation.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes focusing on sulfur amino acid chemistry and redox biology.
• Quality Control Standards: Utilized by pharmaceutical and diagnostic manufacturers as a high-purity calibrant for internal quality control processes.

Basic Information

Product Name	Homocysteine Thiolactone
CAS No.	10593-85-8
Molecular Formula	C5H7NO2S
Molecular Weight	145.18 g/mol
Synonyms	L-Homocysteine thiolactone; 2-Amino-4,5-dihydro-4-thiazolecarboxylic acid; DL-Homocysteine thiolactone; Homocysteine thiolactone hydrochloride; Homocysteine thiolactone (HCl); HCTL; 2-Amino-4-mercaptobutyric acid thiolactone; Thiobutyrine thiolactone
EINECS	234-199-8

Quality Control

Our Homocysteine Thiolactone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by IR spectroscopy, purity determination by HPLC, and specific tests for related substances. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment. We support compliance with relevant research and pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.