Description

2,4-Bis[(Trimethylsilyl)Oxy]Benzoic Acid Trimethylsilyl Ester is a highly functionalized, fully silylated benzoic acid derivative that serves as a versatile and protected synthetic intermediate. Its value lies in its role as a key building block for introducing the 2,4-dihydroxybenzoic acid moiety into complex molecules under anhydrous, non-acidic conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, advanced material science, and organic synthesis who require precise control over sensitive reactions.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring protected phenolic and carboxylic acid functionalities for selective deprotection strategies.
• Organic Synthesis Building Block: Serves as a key precursor for constructing complex organic molecules, including natural product analogs and specialty chemicals, where its trimethylsilyl groups provide temporary protection.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials that incorporate benzoic acid derivatives.
• Agrochemical Synthesis: Acts as an intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Analytical Chemistry Standard: Utilized as a reference standard or derivatization agent in chromatographic analysis (GC, GC-MS) for phenolic compounds.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl structures.

Basic Information

Product Name	2,4-Bis[(Trimethylsilyl)Oxy]Benzoic Acid Trimethylsilyl Ester
CAS No.	10586-16-0
Molecular Formula	C16H30O4Si3
Molecular Weight	370.66 g/mol
Synonyms	Benzoic acid, 2,4-bis[(trimethylsilyl)oxy]-, trimethylsilyl ester; 2,4-Bis(trimethylsiloxy)benzoic acid trimethylsilyl ester; Trimethylsilyl 2,4-bis(trimethylsiloxy)benzoate; 2,4-Dihydroxybenzoic acid tris(trimethylsilyl) ether; Tris-O-trimethylsilyl-2,4-dihydroxybenzoate; TMS-protected 2,4-dihydroxybenzoic acid; 2,4-Bis(TMS-oxy)benzoic acid TMS ester
EINECS	Contact for details

Quality Control

Our 2,4-Bis[(Trimethylsilyl)Oxy]Benzoic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research, development, and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage or when opening containers to prevent hydrolysis of the silyl groups. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.