Description

(1R,2R)-trans-1-(Chloromethyl)-2-Methylcyclopropane is a high-purity, chiral cyclopropane derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable building block for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. Its unique stereochemistry and reactive functional groups make it essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), chiral ligands, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those requiring a rigid, three-membered ring structure for biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the cyclopropane moiety enhances stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Fine Chemical Production: Acts as a critical intermediate in multi-step syntheses for high-value, low-volume specialty chemicals.

Basic Information

Product Name	(1R,2R)-trans-1-(Chloromethyl)-2-Methylcyclopropane
CAS No.	10524-03-5
Molecular Formula	C5H9Cl
Molecular Weight	104.58 g/mol
Synonyms	(1R,2R)-1-(Chloromethyl)-2-methylcyclopropane; trans-1-(Chloromethyl)-2-methylcyclopropane; (1R-cis)-1-(Chloromethyl)-2-methylcyclopropane; 1-Chloromethyl-2-methylcyclopropane; (1R,2R)-1-Chloromethyl-2-methylcyclopropane; trans-2-Methyl-1-(chloromethyl)cyclopropane; (1R,2R)-trans-2-Methyl-1-(chloromethyl)cyclopropane
EINECS	Contact for details

Quality Control

Our (1R,2R)-trans-1-(Chloromethyl)-2-Methylcyclopropane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including chiral HPLC and GC analysis, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat sources and open flames. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.