Description

Potassium Trimethylsilanolate is a highly reactive organosilicon compound that serves as a powerful silylating agent and strong base. This material is critical for introducing the trimethylsilyl (TMS) protecting group in complex organic and pharmaceutical syntheses, enabling precise control over reaction pathways. It is an essential reagent for R&D chemists and production specialists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to protect sensitive functional groups like alcohols and acids.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for protecting hydroxyl groups in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where silylation steps are required for selectivity and yield improvement.
• Polymer & Silicone Chemistry: Acts as an initiator or catalyst in the formation of specialized silicone polymers and as a surface-modifying agent for silica.
• Analytical Derivatization: Employed in Gas Chromatography (GC) and Mass Spectrometry (MS) to derivative polar compounds (e.g., sugars, acids) for improved volatility and detection.
• Organic Synthesis Reagent: A versatile strong base used in deprotonation reactions and for generating other organometallic reagents under anhydrous conditions.
• Electronics & Semiconductor Industry: Used in the deposition of silicon-containing thin films and in the surface passivation of sensitive electronic components.

Basic Information

Item	Detail
Product Name	Potassium Trimethylsilanolate
CAS No.	10519-96-7
Molecular Formula	C3H9KOSi
Molecular Weight	128.29 g/mol
Synonyms	Potassium Trimethylsilanolate; Trimethylsilanol Potassium Salt; Potassium Trimethylsilanol; Trimethylsilyl Potassium; TMSOK; (Trimethylsilyloxy)potassium; Potassium (Trimethylsiloxy); Potassium O-Trimethylsilyl
EINECS	234-054-0

Quality Control

Our Potassium Trimethylsilanolate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly hygroscopic and moisture-sensitive nature, this product must be stored under a dry, inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The container must be kept tightly sealed in a desiccator after opening to prevent decomposition by atmospheric moisture and CO2.

Specification

Item	Specification
Appearance	White to off-white powder or lumps
Identification (IR)	Conforms to structure
Assay (by Titration)	≥ 95.0%
Potassium Content	29.0 - 31.0 %
Solubility (Test)	Soluble in common organic solvents (THF, Toluene)
Loss on Drying	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.