Description

Diphenyleneiodonium Chloride is a potent and selective inhibitor of flavoenzymes, including NADPH oxidase, making it a critical research tool in biochemical and pharmacological studies. Its primary value lies in its ability to modulate reactive oxygen species (ROS) production, which is fundamental for investigating oxidative stress pathways, cellular signaling, and inflammatory responses. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on cardiovascular disease, neurodegeneration, and immunology research.

Application

• Biochemical Research: A key inhibitor for studying NADPH oxidase (NOX) enzyme activity and its role in generating superoxide anions.
• Pharmacological Studies: Used to investigate the mechanisms of oxidative stress in models of cardiovascular diseases, neurodegeneration (e.g., Alzheimer's, Parkinson's), and ischemia-reperfusion injury.
• Cell Signaling Pathway Analysis: Employed to dissect ROS-dependent signaling cascades involved in inflammation, apoptosis, and cell proliferation.
• Antimicrobial Research: Explored for its potential effects on microbial metabolism by targeting bacterial flavoproteins.
• Neuroscience: Utilized in studies examining microglial activation and neuroinflammation.
• Drug Discovery: Serves as a reference compound and starting point for developing novel therapeutics targeting oxidative damage.

Basic Information

Product Name	Diphenyleneiodonium Chloride
CAS No.	10182-84-0
Molecular Formula	C12H8ICl
Molecular Weight	314.55 g/mol
Synonyms	Diphenyleneiodonium Chloride; DPI; 5H-Dibenzo[c,e]iodinium, 5,6-dihydro-, chloride; 5,6-Dihydrodibenzo[c,e]iodinium Chloride; NSC 66311; CCRIS 7341; Iodonium, diphenylene-, chloride; Diphenyleneiodonium (DPI) Chloride
EINECS	233-447-7

Quality Control

Our Diphenyleneiodonium Chloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.