Description

4-Chloronicotinic Acid is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a carboxylic acid and a chloro substituent on the pyridine ring, makes it an essential intermediate for constructing complex pharmacologically active molecules. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and as kinase inhibitors.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used to prepare functionalized pyridine-based ligands for metal catalysis and coordination chemistry.
• Material Science Research: Intermediate in the development of organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes and tags used in biochemical and diagnostic research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	4-Chloronicotinic Acid
CAS No.	10177-29-4
Molecular Formula	C6H4ClNO2
Molecular Weight	157.55 g/mol
Synonyms	4-Chloropyridine-3-carboxylic Acid; 3-Carboxy-4-chloropyridine; Nicotinic Acid, 4-Chloro-; 4-Chloro-3-pyridinecarboxylic Acid; 4-Chloro-3-carboxypyridine; 4-Chloronicotinic Acid; 4-Chloro-3-pyridinylcarboxylic Acid; 4-Chloro-pyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Chloronicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, related substances, and residual solvents. Our quality standards are designed to meet the rigorous demands of GMP-aligned synthesis and global regulatory compliance (e.g., REACH).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.