Description

1,2-Dibromo-3,5-Difluorobenzene is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a versatile precursor for constructing complex molecules where precise electronic and steric properties are required. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing halogenated aromatic motifs that can influence bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluorobenzene core is a common structural element.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atoms are excellent handles for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille), enabling rapid diversification of the benzene core.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on aromatic systems and for synthesizing more complex fluorinated compounds.
• Ligand and Catalyst Development: Used to create novel chelating ligands for catalysis or as a scaffold for functional molecules in supramolecular chemistry.

Basic Information

Product Name	1,2-Dibromo-3,5-Difluorobenzene
CAS No.	10105-60-9
Molecular Formula	C6H2Br2F2
Molecular Weight	271.89 g/mol
Synonyms	3,5-Difluoro-1,2-dibromobenzene; 1,2-Dibromo-3,5-difluorobenzol; Benzene, 1,2-dibromo-3,5-difluoro-; 3,5-Difluoro-o-dibromobenzene; o-Dibromo-3,5-difluorobenzene; 2,3-Dibromo-1,5-difluorobenzene (alternative numbering); DBDFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1,2-Dibromo-3,5-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from GC, HPLC, NMR, and other relevant methods. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.