Description

2-Chloro-4-Fluorophenol is a versatile halogenated phenol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents, provides valuable reactivity and physicochemical properties for creating complex molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Liquid Crystal & Electronic Chemicals: Serves as a precursor in the manufacture of specialty materials for electronic applications.
• Dye & Pigment Intermediate: Employed in the synthesis of complex dyes and organic pigments.
• Polymer Modification: Acts as a monomer or additive to impart specific properties like flame retardancy or stability to polymers.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl structures.
• Research & Development: Used in academic and industrial R&D labs for method development and exploring new chemical entities.

Basic Information

Product Name	2-Chloro-4-Fluorophenol
CAS No.	1996-41-4
Molecular Formula	C6H4ClFO
Molecular Weight	146.55 g/mol
Synonyms	4-Fluoro-2-chlorophenol; 2-Chloro-4-fluorophenol; 2-Chloro-4-fluoro-1-hydroxybenzene; o-Chloro-p-fluorophenol; Phenol, 2-chloro-4-fluoro-; 1-Hydroxy-2-chloro-4-fluorobenzene; 4-Fluoro-2-chloro-1-hydroxybenzene; 2-Cl-4-F-PhOH
EINECS	217-900-8

Quality Control

Our 2-Chloro-4-Fluorophenol is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizers, strong bases, and heat sources. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	32 - 36 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.