Description

2-Amino-3-(2-Bromo-Phenyl)-Propionic Acid is a specialized brominated phenylalanine derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both an amino acid backbone and a halogenated aromatic ring, makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity and specific pharmacophores into peptide-based drug candidates.
• Asymmetric Synthesis: Employed as a starting material or resolving agent in stereoselective catalytic processes to create enantiomerically pure compounds.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric transformations.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Investigated as an intermediate in the synthesis of novel, biologically active compounds for crop protection.

Basic Information

Product Name	2-Amino-3-(2-Bromo-Phenyl)-Propionic Acid
CAS No.	1991-79-3
Molecular Formula	C9H10BrNO2
Molecular Weight	244.09 g/mol
Synonyms	(2-Bromophenyl)alanine; 2-Bromo-DL-phenylalanine; 3-(2-Bromophenyl)alanine; DL-2-Bromophenylalanine; 2-Amino-3-(2-bromophenyl)propanoic acid; α-Amino-2-bromohydrocinnamic acid; (RS)-2-Amino-3-(2-bromophenyl)propionic acid
EINECS	217-884-1

Quality Control

Our production of 2-Amino-3-(2-Bromo-Phenyl)-Propionic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and impurity profiles via advanced chromatographic techniques. A Certificate of Analysis (COA) detailing specifications for identity, assay, related substances, and residual solvents is supplied with each batch, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D- or L- isomer available)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.