Description

4-Hydroxy-3,5-Diiodophenylacetic Acid is a halogenated phenolic acid derivative of significant interest in advanced organic synthesis. This compound serves as a key synthetic intermediate, valued for its iodine substituents which enable further functionalization and cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel chemical entities, including potential contrast agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those targeting thyroid hormone pathways or requiring iodine-containing pharmacophores.
• Contrast Agent Precursor: Used in research for developing X-ray and computed tomography (CT) contrast media due to the high atomic number of iodine.
• Biochemical Research: Serves as a reagent or precursor in biochemical studies, including enzyme inhibition assays and the synthesis of molecular probes.
• Organic Synthesis: Acts as a versatile intermediate for constructing complex molecules via halogen-metal exchange or palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Material Science Research: Investigated for the preparation of specialized polymers or organic electronic materials where halogenated aromatic units are required.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4-Hydroxy-3,5-Diiodophenylacetic Acid
CAS No.	1948-39-6
Molecular Formula	C8H6I2O3
Molecular Weight	403.94 g/mol
Synonyms	3,5-Diiodo-4-hydroxyphenylacetic Acid; (3,5-Diiodo-4-hydroxyphenyl)acetic Acid; 4-Hydroxy-3,5-diiodobenzeneacetic Acid; DIHPA; 2-(3,5-Diiodo-4-hydroxyphenyl)acetic Acid; NSC 403169; 1948-39-6
EINECS	217-771-9

Quality Control

Our 4-Hydroxy-3,5-Diiodophenylacetic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.