Description

(2-Bromobenzyl)Trimethylsilane is a versatile organosilicon reagent featuring a bromobenzyl group protected by a trimethylsilyl (TMS) moiety. This compound is a valuable synthetic intermediate, prized for its dual functionality where the silyl group acts as a protective or directing agent while the bromine serves as a handle for further cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex aromatic frameworks and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Suzuki, Negishi, or Kumada cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and other crop protection agents that require substituted benzyl architectures.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphine ligands or organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers where precise aromatic functionalization is critical.
• Organic Synthesis Reagent: Functions as a benzyl anion equivalent or a masked electrophile in multi-step synthetic sequences under basic conditions.
• Chemical Research & Development: A fundamental tool in academic and industrial laboratories for methodology development and exploring new chemical spaces.

Basic Information

Product Name	(2-Bromobenzyl)Trimethylsilane
CAS No.	1833-44-9
Molecular Formula	C10H15BrSi
Molecular Weight	243.22 g/mol
Synonyms	1-[(2-Bromophenyl)methyl]-1,1,1-trimethylsilane; (2-Bromobenzyl)trimethylsilane; Trimethyl(2-bromobenzyl)silane; 2-Bromobenzyltrimethylsilane; (o-Bromobenzyl)trimethylsilane; Silane, trimethyl[(2-bromophenyl)methyl]-; (2-Bromophenylmethyl)trimethylsilane; α-Trimethylsilyl-o-bromotoluene
EINECS	217-403-8

Quality Control

Our (2-Bromobenzyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.