Description

4-Chlorotetrahydropyran is a versatile chlorinated heterocyclic building block, primarily valued for its reactivity as an alkylating agent and its role as a protected form of 4-chlorobutanol. This compound matters as a key synthetic intermediate, enabling the efficient construction of complex molecules in pharmaceutical and agrochemical research. It is needed by process chemists and R&D teams in the fine chemical, pharmaceutical, and specialty chemical industries for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing tetrahydropyran or piperidine motifs.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and other crop protection agents.
• Organic Synthesis Reagent: Serves as an alkylating agent and a precursor for introducing the 4-chlorobutyl moiety into target molecules in medicinal chemistry.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers and resins.
• Chemical Research: Utilized in academic and industrial R&D for methodological studies and the exploration of new chemical reactions.

Basic Information

Product Name	4-Chlorotetrahydropyran
CAS No.	1768-64-5
Molecular Formula	C5H9ClO
Molecular Weight	120.58 g/mol
Synonyms	4-Chlorooxane; 4-Chlorotetrahydro-2H-pyran; Tetrahydro-4-chloro-2H-pyran; 4-Chloro-tetrahydropyran; 2H-Pyran, tetrahydro-4-chloro-; 4-Chlorotetrahydropyrane; 4-Chloro-tetrahydro-pyran
EINECS	217-195-7

Quality Control

Our 4-Chlorotetrahydropyran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. Due to its sensitivity to light and potential reactivity, it is recommended to use under an inert atmosphere for extended storage periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.460 - 1.470
Density (20°C)	1.10 - 1.20 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.