Description

H-Gly-Obzl (CAS NO 1738-68-7) is a protected glycine derivative, specifically the benzyl ester of N-formylglycine, serving as a crucial chiral building block in advanced organic synthesis. This high-purity intermediate is essential for constructing complex peptide backbones and other biologically active molecules with precise stereochemical control. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of APIs, peptide therapeutics, and specialized agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based active pharmaceutical ingredients (APIs) and protease inhibitors.
• Peptide Chemistry: Used for the controlled introduction of glycine residues under protecting group strategies, minimizing side reactions during solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Serves as a building block for developing novel herbicides and fungicides with specific modes of action.
• Bioconjugation: Employed in the synthesis of linkers and spacers for antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Material Science: A precursor for specialty polymers and dendrimers requiring specific amino acid-based architectures.
• Academic & R&D: A valuable reagent in university and institutional research for exploring new synthetic methodologies and bioactive compound libraries.

Basic Information

Product Name	H-Gly-Obzl
CAS No.	1738-68-7
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	N-Formylglycine benzyl ester; Glycine, N-formyl-, benzyl ester; Benzyl N-formylglycinate; Benzyl 2-formamidoacetate; 2-Formamidoacetic acid benzyl ester; Fmoc-Gly-OBzl (common abbreviation); Bzl-Gly-OH (related protected form); Glycine benzyl ester formyl derivative
EINECS	217-099-8

Quality Control

Our H-Gly-Obzl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of pharmaceutical and advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Chiral Purity	≥ 99.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.